Detection of BRAF V600E Mutation in Colorectal Cancer
نویسندگان
چکیده
منابع مشابه
Evaluation of BRAF-V600E gene mutation in colon tissue of patients with colorectal cancer in Iran
Background: Colorectal cancer is one of the most common types of cancer and the cause of death of a large number of patients and requires investigating the causes of the disease and adopting targeted therapies. Considering the diagnostic, therapeutic, and prognostic significance of genetic markers, in the present study BRAF-V600E gene mutation was evaluated in tissue samples of colorectal cance...
متن کاملBRAF V600E mutation detection by immunohistochemistry in colorectal carcinoma.
The serine/threonine-protein kinase B-raf (BRAF) is an oncogene mutated in various neoplasms, including 5-15% of colorectal carcinomas. The T1799A point mutation, responsible for a large majority of these alterations, results in an amino acid substitution (V600E) causing the constitutive activation of a protein kinase cascade. BRAF V600E in MLH1 deficient tumors implicates somatic tumor-only me...
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aim : we aimed to explore the frequency of braf v600e mutation in iranian patients with colorectal cancer (crc) as well as its association with clinic pathological characteristic of patients. background : crc is the third leading cause of cancer related death. there is a growing body of data showing the association of braf v600e mutation with malignant transformation and clinical outcome of d...
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The BRAF mutant colorectal cancer subgroup is a small population with unique clinicopathological and molecular features. This subgroup has been associated with particularly poor prognosis and advanced disease. The poor response of these patients to available treatments has driven much of the effort in trialling combination targeted treatments involving BRAF and MEK inhibitors. Most recently, an...
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ژورنال
عنوان ژورنال: The Journal of Molecular Diagnostics
سال: 2006
ISSN: 1525-1578
DOI: 10.2353/jmoldx.2006.060070